Blog - Adult Onset Vitelliform Dystrophy
A 41 year old male patient came with history of diminished vision in both eyes since 5 months. His best corrected visual acuity was 6/6 in both eyes with glasses. Fundus evaluation showed subretinal fluid at macula with subretinal fibrin deposition inferior to fovea.
OCT : shows a hyperreflective material between neurosensory retina and RPE
ADULT ONSET VITELLIFORM MACULAR DYSTROPHY(AVMD)
Classically, AVMD changes include
- Sporadic, although some familial clustering has been reported,
- Onset typically between 30-50 years of age,
- Autofluorescent, subfoveal yellow vitelliform-like lesion 500-700µm in size,
- No visual symptoms, or-mild-moderate visual acuity decrease,
- Hyperreflective material between the NSR and the RPE.
Complications of AVMD include:
At present, no definitive therapies or treatments exist for patients with bestrophinopathies.
- Gene therapies
- Stem cell based retinal pigment epithelium transplantation
Both the therapies are under intense research
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